Drug interactions
Midazolam + Nicardipine
Severity: Moderate
Midazolam and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP3A4 to a mild-to-moderate degree and can increase midazolam exposure. Sedation may be stronger or longer, and additive hypotension is possible.
What this interaction means in plain words
Midazolam and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated midazolam metabolism by nicardipine.
What to do
Use a lower initial midazolam dose and titrate to effect; monitor sedation depth, respiration and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Midazolam with Nicardipine?
MediHelp rates the interaction as moderate. Midazolam and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits CYP3A4 to a mild-to-moderate degree and can increase midazolam exposure. Sedation may be stronger or longer, and additive hypotension is possible.
How serious is the interaction between Midazolam and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower initial midazolam dose and titrate to effect; monitor sedation depth, respiration and blood pressure.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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