Drug interactions
Midazolam + Pexidartinib
Severity: Moderate
Midazolam and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CYP3A4 inducer and can reduce midazolam exposure, leading to inadequate sedation or anxiolysis. The effect is greatest with oral dosing.
What this interaction means in plain words
Midazolam and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by pexidartinib increases midazolam metabolism.
What to do
Monitor for reduced effect and titrate midazolam according to response, or use an alternative sedative not metabolized by CYP3A4. Watch for excess sedation if pexidartinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Midazolam with Pexidartinib?
MediHelp rates the interaction as moderate. Midazolam and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is a CYP3A4 inducer and can reduce midazolam exposure, leading to inadequate sedation or anxiolysis. The effect is greatest with oral dosing.
How serious is the interaction between Midazolam and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced effect and titrate midazolam according to response, or use an alternative sedative not metabolized by CYP3A4. Watch for excess sedation if pexidartinib is stopped.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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