Drug interactions
Midazolam + Pramipexole
Severity: Moderate
Midazolam and Pramipexole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pramipexole can cause somnolence and sudden sleep onset, and midazolam adds to sedation. The combination may raise the risk of excessive daytime sleepiness and accidents.
What this interaction means in plain words
Midazolam and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pramipexole belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor sedation after midazolam and warn patients about drowsiness and sudden sleep episodes; reduce midazolam dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Midazolam with Pramipexole?
MediHelp rates the interaction as moderate. Midazolam and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pramipexole can cause somnolence and sudden sleep onset, and midazolam adds to sedation. The combination may raise the risk of excessive daytime sleepiness and accidents.
How serious is the interaction between Midazolam and Pramipexole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation after midazolam and warn patients about drowsiness and sudden sleep episodes; reduce midazolam dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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