Drug interactions
Midazolam + Tetrabenazine
Severity: Moderate
Midazolam and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes sedation and can worsen depression, and midazolam may add to drowsiness and psychomotor impairment. The combination increases the risk of excessive CNS depression.
What this interaction means in plain words
Midazolam and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from VMAT2 inhibition and GABA-A potentiation.
What to do
Use lower midazolam doses and monitor sedation and mood. Advise patients to avoid alcohol and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Midazolam with Tetrabenazine?
MediHelp rates the interaction as moderate. Midazolam and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes sedation and can worsen depression, and midazolam may add to drowsiness and psychomotor impairment. The combination increases the risk of excessive CNS depression.
How serious is the interaction between Midazolam and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower midazolam doses and monitor sedation and mood. Advise patients to avoid alcohol and hazardous activities.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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