Drug interactions
Midazolam + Thioridazine
Severity: Moderate
Midazolam and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can cause deeper and longer sedation and psychomotor impairment. Thioridazine also prolongs the QT interval, which adds concern in a sedated patient who is being monitored less closely.
What this interaction means in plain words
Midazolam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and phenothiazine antihistaminic and antiadrenergic effects.
What to do
Use the lowest effective midazolam dose and titrate slowly, monitoring sedation level and respiration. Check the ECG and electrolytes in patients on thioridazine who need repeated sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Midazolam with Thioridazine?
MediHelp rates the interaction as moderate. Midazolam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can cause deeper and longer sedation and psychomotor impairment. Thioridazine also prolongs the QT interval, which adds concern in a sedated patient who is being monitored less closely.
How serious is the interaction between Midazolam and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective midazolam dose and titrate slowly, monitoring sedation level and respiration. Check the ECG and electrolytes in patients on thioridazine who need repeated sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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