Drug interactions
Midazolam + Ticagrelor
Severity: Minor
Midazolam and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor and can modestly raise exposure to sensitive CYP3A4 substrates such as midazolam. This may slightly intensify or prolong sedation, particularly with oral or intranasal dosing.
What this interaction means in plain words
Midazolam and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak inhibition of intestinal and hepatic CYP3A4 by ticagrelor reduces midazolam metabolism.
What to do
No dose change is usually needed; observe the level of sedation and respiratory status after midazolam dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Midazolam with Ticagrelor?
MediHelp rates the interaction as minor. Midazolam and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A4 inhibitor and can modestly raise exposure to sensitive CYP3A4 substrates such as midazolam. This may slightly intensify or prolong sedation, particularly with oral or intranasal dosing.
How serious is the interaction between Midazolam and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; observe the level of sedation and respiratory status after midazolam dosing.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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