Drug interactions
Midazolam + Vonoprazan
Severity: Minor
Midazolam and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and may modestly raise exposure to midazolam, a sensitive CYP3A substrate. Sedation could be somewhat deeper or longer, particularly with oral midazolam.
What this interaction means in plain words
Midazolam and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A4-mediated midazolam metabolism by vonoprazan.
What to do
Monitor sedation level and recovery time when oral midazolam is given with vonoprazan; reduce the midazolam dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Midazolam with Vonoprazan?
MediHelp rates the interaction as minor. Midazolam and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is a weak CYP3A inhibitor and may modestly raise exposure to midazolam, a sensitive CYP3A substrate. Sedation could be somewhat deeper or longer, particularly with oral midazolam.
How serious is the interaction between Midazolam and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and recovery time when oral midazolam is given with vonoprazan; reduce the midazolam dose if excessive sedation occurs.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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