Drug interactions
Midazolam + Voxelotor
Severity: Moderate
Midazolam and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can increase midazolam exposure, potentially prolonging sedation. The risk is greater with oral dosing.
What this interaction means in plain words
Midazolam and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibition of CYP3A4 reduces midazolam clearance.
What to do
Consider a reduced midazolam dose and monitor sedation and respiration. Use a non-CYP3A4 benzodiazepine if repeated dosing is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Midazolam with Voxelotor?
MediHelp rates the interaction as moderate. Midazolam and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can increase midazolam exposure, potentially prolonging sedation. The risk is greater with oral dosing.
How serious is the interaction between Midazolam and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced midazolam dose and monitor sedation and respiration. Use a non-CYP3A4 benzodiazepine if repeated dosing is needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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