Drug interactions
Midazolam intranasal + Progesterone
Severity: Minor
Midazolam intranasal and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a sensitive CYP3A4 substrate, and progesterone may weakly inhibit its metabolism. Sedation could be somewhat prolonged, though the effect is probably small.
What this interaction means in plain words
Midazolam intranasal and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by progesterone reducing midazolam clearance.
What to do
Monitor sedation and respiratory status after intranasal midazolam; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Frequently asked questions
Can I take Midazolam intranasal with Progesterone?
MediHelp rates the interaction as minor. Midazolam intranasal and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is a sensitive CYP3A4 substrate, and progesterone may weakly inhibit its metabolism. Sedation could be somewhat prolonged, though the effect is probably small.
How serious is the interaction between Midazolam intranasal and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after intranasal midazolam; no routine dose change is needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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