Drug interactions
Midodrine + Oxazepam
Severity: Minor
Midodrine and Oxazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established pharmacokinetic or significant pharmacodynamic interaction between these two drugs. Oxazepam may cause sedation and hypotension, which midodrine does not meaningfully offset.
What this interaction means in plain words
Midodrine and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midodrine belongs to Miscellaneous; Oxazepam belongs to Central Nervous System.
Why it happens
No established mechanism; theoretical opposing effects on blood pressure and alertness.
What to do
No specific action is needed beyond routine monitoring of blood pressure and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Oxazepam?
MediHelp rates the interaction as minor. Midodrine and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established pharmacokinetic or significant pharmacodynamic interaction between these two drugs. Oxazepam may cause sedation and hypotension, which midodrine does not meaningfully offset.
How serious is the interaction between Midodrine and Oxazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of blood pressure and sedation.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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