Drug interactions
Midodrine + Oxymetazoline
Severity: Moderate
Midodrine and Oxymetazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and oxymetazoline adds further alpha-mediated vasoconstriction. Together they may increase the risk of hypertension, including supine hypertension, and reflex bradycardia.
What this interaction means in plain words
Midodrine and Oxymetazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Oxymetazoline belongs to Respiratory.
Why it happens
Additive alpha-1 adrenergic agonist vasoconstriction.
What to do
Monitor blood pressure, including supine readings, and limit oxymetazoline use in patients taking midodrine; consider a non-adrenergic decongestant such as saline or intranasal corticosteroid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymetazoline
- Isocarboxazid + Oxymetazoline Major
- Oxymetazoline + Phenelzine Major
- Oxymetazoline + Tranylcypromine Major
- Amitriptyline + Oxymetazoline Moderate
- Amoxapine + Oxymetazoline Moderate
- Clomipramine + Oxymetazoline Moderate
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Oxymetazoline?
MediHelp rates the interaction as moderate. Midodrine and Oxymetazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and oxymetazoline adds further alpha-mediated vasoconstriction. Together they may increase the risk of hypertension, including supine hypertension, and reflex bradycardia.
How serious is the interaction between Midodrine and Oxymetazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and limit oxymetazoline use in patients taking midodrine; consider a non-adrenergic decongestant such as saline or intranasal corticosteroid.
What other medicines interact with Oxymetazoline?
MediHelp also lists interactions of Oxymetazoline with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Oxymetazoline page.
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