Drug interactions
Midodrine + Safinamide
Severity: Moderate
Midodrine and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and safinamide, a MAO-B inhibitor, may enhance pressor responses to sympathomimetics. Together they may cause hypertension, which is of particular concern because midodrine already causes supine hypertension.
What this interaction means in plain words
Midodrine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Safinamide belongs to Central Nervous System.
Why it happens
Additive adrenergic pressor effects, with possible potentiation of sympathomimetic action by MAO-B inhibition.
What to do
Monitor blood pressure, including supine readings, when combining them. Lower the midodrine dose or stop it if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Safinamide?
MediHelp rates the interaction as moderate. Midodrine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and safinamide, a MAO-B inhibitor, may enhance pressor responses to sympathomimetics. Together they may cause hypertension, which is of particular concern because midodrine already causes supine hypertension.
How serious is the interaction between Midodrine and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, when combining them. Lower the midodrine dose or stop it if hypertension develops.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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