Drug interactions
Midodrine + Salbutamol
Severity: Moderate
Midodrine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and salbutamol adds beta-adrenergic cardiac stimulation. Together they may increase heart rate, blood pressure and the risk of palpitations or arrhythmias.
What this interaction means in plain words
Midodrine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Salbutamol belongs to Respiratory.
Why it happens
Additive adrenergic effects through alpha-1 vasoconstriction and beta-agonist cardiac stimulation.
What to do
Monitor blood pressure, including supine readings, and heart rate. Reduce doses if hypertension or tachyarrhythmia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Salbutamol?
MediHelp rates the interaction as moderate. Midodrine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure, and salbutamol adds beta-adrenergic cardiac stimulation. Together they may increase heart rate, blood pressure and the risk of palpitations or arrhythmias.
How serious is the interaction between Midodrine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate. Reduce doses if hypertension or tachyarrhythmia occurs.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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