Drug interactions
Midostaurin + Oxcarbazepine
Severity: Major
Midostaurin and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower midostaurin and metabolite exposure through CYP3A4 induction. Strong inducers markedly reduce exposure, and oxcarbazepine is weaker. Efficacy in AML or mastocytosis may be reduced.
What this interaction means in plain words
Midostaurin and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midostaurin belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases midostaurin metabolism.
What to do
Prefer a non-inducing anticonvulsant such as levetiracetam, and monitor disease response if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Oxcarbazepine?
MediHelp rates the interaction as major. Midostaurin and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may lower midostaurin and metabolite exposure through CYP3A4 induction. Strong inducers markedly reduce exposure, and oxcarbazepine is weaker. Efficacy in AML or mastocytosis may be reduced.
How serious is the interaction between Midostaurin and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant such as levetiracetam, and monitor disease response if combined.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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