Drug interactions
Mifepristone + Osimertinib
Severity: Moderate
Mifepristone and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may modestly raise osimertinib exposure through CYP3A4 inhibition. Osimertinib has QT-prolonging potential, and higher exposure may increase that risk along with other adverse effects.
What this interaction means in plain words
Mifepristone and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Osimertinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of osimertinib by mifepristone, with additive QT effects.
What to do
Monitor ECG and electrolytes if the combination cannot be avoided. Watch for osimertinib adverse effects such as interstitial lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Mifepristone with Osimertinib?
MediHelp rates the interaction as moderate. Mifepristone and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may modestly raise osimertinib exposure through CYP3A4 inhibition. Osimertinib has QT-prolonging potential, and higher exposure may increase that risk along with other adverse effects.
How serious is the interaction between Mifepristone and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if the combination cannot be avoided. Watch for osimertinib adverse effects such as interstitial lung disease.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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