Drug interactions
Mifepristone + Perphenazine
Severity: Major
Mifepristone and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, especially at Cushing syndrome doses, prolongs the QT interval, as can perphenazine. Combined use may increase the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Mifepristone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; mifepristone also inhibits CYP3A4 and may alter exposure to co-administered drugs.
What to do
Use an alternative to one of the drugs where possible. If combined, perform baseline and follow-up ECGs and maintain normal potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Perphenazine?
MediHelp rates the interaction as major. Mifepristone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, especially at Cushing syndrome doses, prolongs the QT interval, as can perphenazine. Combined use may increase the risk of serious ventricular arrhythmias.
How serious is the interaction between Mifepristone and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to one of the drugs where possible. If combined, perform baseline and follow-up ECGs and maintain normal potassium and magnesium.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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