Drug interactions
Mifepristone + Rimegepant
Severity: Moderate
Mifepristone and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is a CYP3A4 substrate, and strong inhibitors increase its exposure. Mifepristone may therefore raise rimegepant concentrations, with likely increased adverse effects such as nausea and hypersensitivity.
What this interaction means in plain words
Mifepristone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Rimegepant belongs to Central Nervous System.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of rimegepant.
What to do
Avoid taking another rimegepant dose within 48 hours of a strong CYP3A4 inhibitor, per labeling. Consider an alternative acute migraine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mifepristone and Rimegepant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Mifepristone with Rimegepant?
MediHelp rates the interaction as moderate. Mifepristone and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rimegepant is a CYP3A4 substrate, and strong inhibitors increase its exposure. Mifepristone may therefore raise rimegepant concentrations, with likely increased adverse effects such as nausea and hypersensitivity.
How serious is the interaction between Mifepristone and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking another rimegepant dose within 48 hours of a strong CYP3A4 inhibitor, per labeling. Consider an alternative acute migraine therapy.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
