Drug interactions
Mifepristone + Ripretinib
Severity: Moderate
Mifepristone and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase exposure to ripretinib and its active metabolite. This may increase adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
What this interaction means in plain words
Mifepristone and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Ripretinib belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, reducing metabolism of ripretinib and its active metabolite.
What to do
Monitor for ripretinib adverse reactions and interrupt or reduce the dose if they occur. Consider an alternative to mifepristone if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Mifepristone with Ripretinib?
MediHelp rates the interaction as moderate. Mifepristone and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase exposure to ripretinib and its active metabolite. This may increase adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
How serious is the interaction between Mifepristone and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ripretinib adverse reactions and interrupt or reduce the dose if they occur. Consider an alternative to mifepristone if possible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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