Drug interactions
Mifepristone + Rosiglitazone
Severity: Moderate
Mifepristone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP2C8, the main pathway of rosiglitazone clearance, so rosiglitazone levels may increase. This can strengthen glucose lowering and add to fluid retention and edema risk.
What this interaction means in plain words
Mifepristone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP2C8 (and CYP2C9) metabolism of rosiglitazone.
What to do
Use the lowest effective rosiglitazone dose and monitor blood glucose and signs of fluid retention or heart failure. Adjust the dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mifepristone and Rosiglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Mifepristone with Rosiglitazone?
MediHelp rates the interaction as moderate. Mifepristone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP2C8, the main pathway of rosiglitazone clearance, so rosiglitazone levels may increase. This can strengthen glucose lowering and add to fluid retention and edema risk.
How serious is the interaction between Mifepristone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosiglitazone dose and monitor blood glucose and signs of fluid retention or heart failure. Adjust the dose according to response.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
