Drug interactions
Mifepristone + Sonidegib
Severity: Major
Mifepristone and Sonidegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is a CYP3A4 substrate, and mifepristone can increase its plasma levels. This raises the risk of musculoskeletal toxicity such as myalgia and CK elevation, which can progress to rhabdomyolysis.
What this interaction means in plain words
Mifepristone and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Sonidegib belongs to Oncology.
Why it happens
Mifepristone inhibits CYP3A4, reducing sonidegib clearance.
What to do
Avoid the combination. If it is needed for a short period, monitor serum creatine kinase and muscle symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Mifepristone with Sonidegib?
MediHelp rates the interaction as major. Mifepristone and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sonidegib is a CYP3A4 substrate, and mifepristone can increase its plasma levels. This raises the risk of musculoskeletal toxicity such as myalgia and CK elevation, which can progress to rhabdomyolysis.
How serious is the interaction between Mifepristone and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it is needed for a short period, monitor serum creatine kinase and muscle symptoms closely.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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