Drug interactions
Mifepristone + Tipranavir
Severity: Major
Mifepristone and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir has mixed effects on CYP3A4, including strong inhibition, and may increase mifepristone concentrations. Higher mifepristone exposure can intensify its adverse effects, including QT prolongation, hypokalemia and adrenal insufficiency effects at higher doses.
What this interaction means in plain words
Mifepristone and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir inhibits CYP3A4, decreasing mifepristone clearance.
What to do
Avoid if possible; if both are required, use the lowest effective mifepristone dose and monitor ECG, potassium and clinical effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Mifepristone with Tipranavir?
MediHelp rates the interaction as major. Mifepristone and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted tipranavir has mixed effects on CYP3A4, including strong inhibition, and may increase mifepristone concentrations. Higher mifepristone exposure can intensify its adverse effects, including QT prolongation, hypokalemia and adrenal insufficiency effects at higher doses.
How serious is the interaction between Mifepristone and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are required, use the lowest effective mifepristone dose and monitor ECG, potassium and clinical effects.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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