Drug interactions
Mifepristone + Velpatasvir
Severity: Minor
Mifepristone and Velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase velpatasvir exposure through CYP3A4 inhibition. The effect is likely modest because velpatasvir has multiple elimination routes.
What this interaction means in plain words
Mifepristone and Velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Velpatasvir belongs to Anti Virals.
Why it happens
Mifepristone inhibits CYP3A4 (and possibly P-gp), decreasing velpatasvir clearance.
What to do
No routine adjustment is needed; monitor for velpatasvir adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mifepristone and Velpatasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Mifepristone with Velpatasvir?
MediHelp rates the interaction as minor. Mifepristone and Velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may increase velpatasvir exposure through CYP3A4 inhibition. The effect is likely modest because velpatasvir has multiple elimination routes.
How serious is the interaction between Mifepristone and Velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for velpatasvir adverse effects such as headache and fatigue.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
