Drug interactions
Mifepristone + Voriconazole
Severity: Major
Mifepristone and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may raise voriconazole concentrations, and both drugs can prolong the QT interval. This increases the risk of voriconazole toxicity and arrhythmia, particularly with the chronic higher doses used for Cushing syndrome.
What this interaction means in plain words
Mifepristone and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Mifepristone inhibits CYP3A4 and voriconazole inhibits mifepristone metabolism, with additive QT effects.
What to do
Avoid concurrent use where possible; if needed, monitor ECG, electrolytes, liver function and voriconazole levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Voriconazole?
MediHelp rates the interaction as major. Mifepristone and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone may raise voriconazole concentrations, and both drugs can prolong the QT interval. This increases the risk of voriconazole toxicity and arrhythmia, particularly with the chronic higher doses used for Cushing syndrome.
How serious is the interaction between Mifepristone and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if needed, monitor ECG, electrolytes, liver function and voriconazole levels.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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