Drug interactions
Mifepristone + Vorinostat
Severity: Moderate
Mifepristone and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QTc prolongation, so concurrent use may raise the risk of ventricular arrhythmias. The risk is greater with electrolyte imbalance or cardiac disease.
What this interaction means in plain words
Mifepristone and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Additive QTc prolongation through pharmacodynamic synergism.
What to do
Obtain baseline and periodic ECGs and correct potassium and magnesium; consider alternatives if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Mifepristone with Vorinostat?
MediHelp rates the interaction as moderate. Mifepristone and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QTc prolongation, so concurrent use may raise the risk of ventricular arrhythmias. The risk is greater with electrolyte imbalance or cardiac disease.
How serious is the interaction between Mifepristone and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct potassium and magnesium; consider alternatives if QTc lengthens.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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