Drug interactions
Milnacipran + Nabumetone
Severity: Moderate
Milnacipran and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Milnacipran, a serotonin-norepinephrine reuptake inhibitor, impairs platelet function, and combined with an NSAID this increases the risk of bleeding, particularly in the upper gastrointestinal tract.
What this interaction means in plain words
Milnacipran and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Milnacipran belongs to Central Nervous System; Nabumetone belongs to Musculoskeletal.
Why it happens
Depletion of platelet serotonin by reuptake inhibition combined with NSAID-mediated platelet inhibition and gastric mucosal injury.
What to do
Monitor for signs of GI bleeding such as melena or anemia, and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Milnacipran with Nabumetone?
MediHelp rates the interaction as moderate. Milnacipran and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Milnacipran, a serotonin-norepinephrine reuptake inhibitor, impairs platelet function, and combined with an NSAID this increases the risk of bleeding, particularly in the upper gastrointestinal tract.
How serious is the interaction between Milnacipran and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding such as melena or anemia, and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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