Drug interactions
Minocycline + Pretomanid
Severity: Moderate
Minocycline and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with liver injury, and minocycline can also cause hepatotoxicity in rare cases. Using both together may add to the risk of liver injury and make it harder to attribute a rise in liver enzymes.
What this interaction means in plain words
Minocycline and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Minocycline belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive potential hepatotoxicity from two agents with independent liver-injury risk; no pharmacokinetic interaction is established.
What to do
Check baseline and regular liver function tests during therapy and stop the suspected agent if transaminases or bilirubin rise significantly. Prefer a non-hepatotoxic alternative to minocycline when one exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Minocycline with Pretomanid?
MediHelp rates the interaction as moderate. Minocycline and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid-containing regimens are associated with liver injury, and minocycline can also cause hepatotoxicity in rare cases. Using both together may add to the risk of liver injury and make it harder to attribute a rise in liver enzymes.
How serious is the interaction between Minocycline and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and regular liver function tests during therapy and stop the suspected agent if transaminases or bilirubin rise significantly. Prefer a non-hepatotoxic alternative to minocycline when one exists.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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