Drug interactions
Mirabegron + Nebivolol
Severity: Moderate
Mirabegron and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is metabolised by CYP2D6, so mirabegron may increase its exposure. This may lead to bradycardia and hypotension, especially in poor CYP2D6 metabolisers.
What this interaction means in plain words
Mirabegron and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Nebivolol belongs to Cardiovascular.
Why it happens
Mirabegron inhibits CYP2D6, decreasing nebivolol clearance.
What to do
Monitor heart rate and blood pressure, and reduce the nebivolol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Mirabegron with Nebivolol?
MediHelp rates the interaction as moderate. Mirabegron and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is metabolised by CYP2D6, so mirabegron may increase its exposure. This may lead to bradycardia and hypotension, especially in poor CYP2D6 metabolisers.
How serious is the interaction between Mirabegron and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce the nebivolol dose if excessive beta-blockade occurs.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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