Drug interactions
Mirabegron + Oliceridine
Severity: Moderate
Mirabegron and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is cleared mainly by CYP3A4 and CYP2D6, so inhibition of CYP2D6 by mirabegron can increase opioid exposure. This may intensify sedation and respiratory depression.
What this interaction means in plain words
Mirabegron and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Oliceridine belongs to Musculoskeletal.
Why it happens
Mirabegron inhibits CYP2D6, reducing oliceridine metabolism.
What to do
Monitor for sedation and respiratory depression and lengthen dosing intervals or lower doses as needed. If mirabegron is stopped, reassess oliceridine dosing for loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Mirabegron with Oliceridine?
MediHelp rates the interaction as moderate. Mirabegron and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is cleared mainly by CYP3A4 and CYP2D6, so inhibition of CYP2D6 by mirabegron can increase opioid exposure. This may intensify sedation and respiratory depression.
How serious is the interaction between Mirabegron and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and lengthen dosing intervals or lower doses as needed. If mirabegron is stopped, reassess oliceridine dosing for loss of effect.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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