Drug interactions
Mirabegron + Ritonavir
Severity: Minor
Mirabegron and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is mainly cleared by CYP3A4 with a minor CYP2D6 role, so mirabegron is unlikely to change its levels meaningfully. In the other direction, ritonavir may raise mirabegron exposure through CYP3A and P-gp inhibition, which is the more relevant effect.
What this interaction means in plain words
Mirabegron and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Ritonavir belongs to Anti Virals.
Why it happens
Mirabegron CYP2D6 inhibition affects only a minor ritonavir pathway.
What to do
No adjustment of ritonavir is needed; monitor blood pressure and heart rate for increased mirabegron effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Mirabegron with Ritonavir?
MediHelp rates the interaction as minor. Mirabegron and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir is mainly cleared by CYP3A4 with a minor CYP2D6 role, so mirabegron is unlikely to change its levels meaningfully. In the other direction, ritonavir may raise mirabegron exposure through CYP3A and P-gp inhibition, which is the more relevant effect.
How serious is the interaction between Mirabegron and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment of ritonavir is needed; monitor blood pressure and heart rate for increased mirabegron effects.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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