Drug interactions
Mirabegron + Sertraline
Severity: Minor
Mirabegron and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is metabolised by several enzymes with only a minor CYP2D6 contribution. Any rise in sertraline exposure from mirabegron is expected to be small.
What this interaction means in plain words
Mirabegron and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Sertraline belongs to Central Nervous System.
Why it happens
Mirabegron weakly inhibits CYP2D6, a minor pathway for sertraline.
What to do
No dose adjustment is usually needed; monitor tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Mirabegron with Sertraline?
MediHelp rates the interaction as minor. Mirabegron and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is metabolised by several enzymes with only a minor CYP2D6 contribution. Any rise in sertraline exposure from mirabegron is expected to be small.
How serious is the interaction between Mirabegron and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor tolerability.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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