Drug interactions
Mirtazapine + Ofloxacin
Severity: Moderate
Mirtazapine and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been associated with QT prolongation, mainly in overdose or with risk factors, and ofloxacin has a modest QT effect. Combined use may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Mirtazapine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check ECG and correct potassium and magnesium in patients with cardiac disease or other QT-prolonging drugs. Consider another antibiotic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Ofloxacin?
MediHelp rates the interaction as moderate. Mirtazapine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine has been associated with QT prolongation, mainly in overdose or with risk factors, and ofloxacin has a modest QT effect. Combined use may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Mirtazapine and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium in patients with cardiac disease or other QT-prolonging drugs. Consider another antibiotic if risk is high.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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