Drug interactions
Mirtazapine + Pasireotide
Severity: Moderate
Mirtazapine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and cause bradycardia, and mirtazapine has been linked to QT prolongation, mainly in overdose or at-risk patients. Combined use may increase the risk of arrhythmia.
What this interaction means in plain words
Mirtazapine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization, with pasireotide-induced bradycardia as a further risk factor.
What to do
Perform baseline and follow-up ECG monitoring and check potassium and magnesium. Avoid combining with further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Mirtazapine with Pasireotide?
MediHelp rates the interaction as moderate. Mirtazapine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and cause bradycardia, and mirtazapine has been linked to QT prolongation, mainly in overdose or at-risk patients. Combined use may increase the risk of arrhythmia.
How serious is the interaction between Mirtazapine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline and follow-up ECG monitoring and check potassium and magnesium. Avoid combining with further QT-prolonging drugs.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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