Drug interactions
Mirtazapine + Pazopanib
Severity: Major
Mirtazapine and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is labeled with a warning for QT prolongation and torsades de pointes. Mirtazapine may add to this effect, increasing arrhythmia risk.
What this interaction means in plain words
Mirtazapine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mirtazapine belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation; pazopanib also inhibits CYP3A4 and may modestly increase mirtazapine levels.
What to do
Use an alternative antidepressant if possible. If both are required, monitor ECG and electrolytes at baseline and periodically during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Mirtazapine with Pazopanib?
MediHelp rates the interaction as major. Mirtazapine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib is labeled with a warning for QT prolongation and torsades de pointes. Mirtazapine may add to this effect, increasing arrhythmia risk.
How serious is the interaction between Mirtazapine and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antidepressant if possible. If both are required, monitor ECG and electrolytes at baseline and periodically during therapy.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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