Drug interactions
Mirtazapine + Sorafenib
Severity: Moderate
Mirtazapine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and mirtazapine may add a small effect. The combination may increase arrhythmia risk, particularly when electrolytes are disturbed.
What this interaction means in plain words
Mirtazapine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Repeat ECG monitoring during sorafenib therapy and consider an alternative antidepressant if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Mirtazapine with Sorafenib?
MediHelp rates the interaction as moderate. Mirtazapine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and mirtazapine may add a small effect. The combination may increase arrhythmia risk, particularly when electrolytes are disturbed.
How serious is the interaction between Mirtazapine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Repeat ECG monitoring during sorafenib therapy and consider an alternative antidepressant if the QTc becomes prolonged.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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