Drug interactions
Mitotane + Omeprazole
Severity: Minor
Mitotane and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane strongly induces CYP3A4 and can lower omeprazole exposure, possibly reducing acid suppression. The effect is usually modest because omeprazole is mainly cleared by CYP2C19.
What this interaction means in plain words
Mitotane and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mitotane belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Mitotane induces hepatic and intestinal CYP enzymes, increasing omeprazole metabolism.
What to do
Monitor for reduced control of reflux or ulcer symptoms and increase the omeprazole dose if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Omeprazole?
MediHelp rates the interaction as minor. Mitotane and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mitotane strongly induces CYP3A4 and can lower omeprazole exposure, possibly reducing acid suppression. The effect is usually modest because omeprazole is mainly cleared by CYP2C19.
How serious is the interaction between Mitotane and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced control of reflux or ulcer symptoms and increase the omeprazole dose if symptoms persist.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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