Drug interactions
Mitotane + Solifenacin
Severity: Moderate
Mitotane and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can substantially lower solifenacin concentrations, possibly causing loss of efficacy. The induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Mitotane and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 by mitotane increases solifenacin metabolism.
What to do
Monitor urinary symptom control and titrate solifenacin to effect, or consider an alternative agent not dependent on CYP3A4; reassess the dose when mitotane is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Solifenacin?
MediHelp rates the interaction as moderate. Mitotane and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can substantially lower solifenacin concentrations, possibly causing loss of efficacy. The induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Mitotane and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and titrate solifenacin to effect, or consider an alternative agent not dependent on CYP3A4; reassess the dose when mitotane is withdrawn.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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