Drug interactions
Mitoxantrone + Oteseconazole
Severity: Moderate
Mitoxantrone and Oteseconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP, a transporter involved in mitoxantrone efflux and elimination. Exposure to mitoxantrone may rise, increasing the risk of bone marrow suppression and cardiotoxicity. Oteseconazole has a very long half-life, so the effect may persist.
What this interaction means in plain words
Mitoxantrone and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Oteseconazole belongs to Anti Fungals.
Why it happens
Oteseconazole inhibits BCRP, reducing efflux and clearance of mitoxantrone.
What to do
Monitor complete blood counts and cardiac status closely. Consider using the lowest effective mitoxantrone dose, or choose an alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Mitoxantrone with Oteseconazole?
MediHelp rates the interaction as moderate. Mitoxantrone and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP, a transporter involved in mitoxantrone efflux and elimination. Exposure to mitoxantrone may rise, increasing the risk of bone marrow suppression and cardiotoxicity. Oteseconazole has a very long half-life, so the effect may persist.
How serious is the interaction between Mitoxantrone and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and cardiac status closely. Consider using the lowest effective mitoxantrone dose, or choose an alternative if feasible.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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