Drug interactions
Mitoxantrone + Vadadustat
Severity: Moderate
Mitoxantrone and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP, and mitoxantrone is a BCRP substrate, so mitoxantrone exposure may increase. This may enhance myelosuppression and cardiotoxicity.
What this interaction means in plain words
Mitoxantrone and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of BCRP-mediated efflux of mitoxantrone by vadadustat.
What to do
Monitor blood counts and cardiac function, and consider reducing the mitoxantrone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Mitoxantrone with Vadadustat?
MediHelp rates the interaction as moderate. Mitoxantrone and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP, and mitoxantrone is a BCRP substrate, so mitoxantrone exposure may increase. This may enhance myelosuppression and cardiotoxicity.
How serious is the interaction between Mitoxantrone and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider reducing the mitoxantrone dose if adverse effects occur.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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