Drug interactions
Mobocertinib + Posaconazole
Severity: Major
Mobocertinib and Posaconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises mobocertinib exposure through CYP3A4 inhibition, and both agents prolong the QT interval. This combination increases the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Mobocertinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition increases mobocertinib levels, with additive QTc prolongation.
What to do
Avoid the combination and use an alternative antifungal. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes more frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Mobocertinib with Posaconazole?
MediHelp rates the interaction as major. Mobocertinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole raises mobocertinib exposure through CYP3A4 inhibition, and both agents prolong the QT interval. This combination increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Mobocertinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antifungal. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes more frequently.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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