Drug interactions
Modafinil + Morphine
Severity: Minor
Modafinil and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and may partly mask morphine-related drowsiness, but it does not reverse respiratory depression. Modafinil induces CYP3A4, which has a minor role in morphine metabolism, so clinically important changes in morphine exposure are unlikely.
What this interaction means in plain words
Modafinil and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Opposing CNS effects; weak enzyme induction by modafinil with little relevance to morphine glucuronidation.
What to do
No dose adjustment is usually needed. Assess analgesia and respiratory status rather than relying on alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Morphine?
MediHelp rates the interaction as minor. Modafinil and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness and may partly mask morphine-related drowsiness, but it does not reverse respiratory depression. Modafinil induces CYP3A4, which has a minor role in morphine metabolism, so clinically important changes in morphine exposure are unlikely.
How serious is the interaction between Modafinil and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Assess analgesia and respiratory status rather than relying on alertness.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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