Drug interactions
Modafinil + Norgestrel
Severity: Major
Modafinil and Norgestrel: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil induces CYP3A4, which can lower progestin concentrations and reduce contraceptive efficacy. Effects may persist for weeks after modafinil is stopped.
What this interaction means in plain words
Modafinil and Norgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Modafinil belongs to Central Nervous System; Norgestrel belongs to Endocrine.
Why it happens
Modafinil induction of CYP3A4 increases metabolism of norgestrel.
What to do
Advise an additional or alternative non-hormonal contraceptive method during modafinil use and for about a month after stopping.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Modafinil
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Modafinil with Norgestrel?
MediHelp rates the interaction as major. Modafinil and Norgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil induces CYP3A4, which can lower progestin concentrations and reduce contraceptive efficacy. Effects may persist for weeks after modafinil is stopped.
How serious is the interaction between Modafinil and Norgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during modafinil use and for about a month after stopping.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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