Drug interactions
Modafinil + Oxazepam
Severity: Minor
Modafinil and Oxazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is wakefulness-promoting and may partially counteract oxazepam sedation, but it does not reliably reverse benzodiazepine impairment. Modafinil may also induce CYP3A4, though oxazepam is cleared mainly by glucuronidation, so a kinetic effect is unlikely.
What this interaction means in plain words
Modafinil and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; no significant pharmacokinetic interaction is expected for oxazepam.
What to do
No dose adjustment is required; monitor for therapeutic response and anxiety or insomnia. Patients should not assume they can drive safely despite the stimulant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Oxazepam?
MediHelp rates the interaction as minor. Modafinil and Oxazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is wakefulness-promoting and may partially counteract oxazepam sedation, but it does not reliably reverse benzodiazepine impairment. Modafinil may also induce CYP3A4, though oxazepam is cleared mainly by glucuronidation, so a kinetic effect is unlikely.
How serious is the interaction between Modafinil and Oxazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for therapeutic response and anxiety or insomnia. Patients should not assume they can drive safely despite the stimulant.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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