Drug interactions
Modafinil + Phenelzine
Severity: Major
Modafinil and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil has sympathomimetic-like effects, and with an MAOI there is concern for raised blood pressure and excessive CNS stimulation. The data are limited, but labeling advises caution, and the legacy classification is stricter than the evidence supports.
What this interaction means in plain words
Modafinil and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Modafinil belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Modafinil's dopaminergic and noradrenergic effects may be potentiated by MAO inhibition; the mechanism is not firmly established.
What to do
Avoid if possible; if combined, monitor blood pressure and heart rate closely and watch for agitation or hyperthermia. Consider an alternative wakefulness strategy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Phenelzine?
MediHelp rates the interaction as major. Modafinil and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil has sympathomimetic-like effects, and with an MAOI there is concern for raised blood pressure and excessive CNS stimulation. The data are limited, but labeling advises caution, and the legacy classification is stricter than the evidence supports.
How serious is the interaction between Modafinil and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, monitor blood pressure and heart rate closely and watch for agitation or hyperthermia. Consider an alternative wakefulness strategy.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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