Drug interactions
Modafinil + Pirtobrutinib
Severity: Major
Modafinil and Pirtobrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may lower pirtobrutinib exposure and its antitumor efficacy. Labeling recommends avoiding strong and moderate CYP3A inducers.
What this interaction means in plain words
Modafinil and Pirtobrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Modafinil belongs to Central Nervous System; Pirtobrutinib belongs to Oncology.
Why it happens
Modafinil induces CYP3A4, increasing pirtobrutinib clearance.
What to do
Avoid the combination; if unavoidable, increase the pirtobrutinib dose per labeling and monitor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Modafinil
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Modafinil with Pirtobrutinib?
MediHelp rates the interaction as major. Modafinil and Pirtobrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Modafinil may lower pirtobrutinib exposure and its antitumor efficacy. Labeling recommends avoiding strong and moderate CYP3A inducers.
How serious is the interaction between Modafinil and Pirtobrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, increase the pirtobrutinib dose per labeling and monitor response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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