Drug interactions
Modafinil + Rasagiline
Severity: Moderate
Modafinil and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a selective MAO-B inhibitor and modafinil is a wake-promoting agent with some catecholaminergic activity. Labeling advises caution with MAO inhibitors, as hypertensive reactions are theoretically possible, although selective MAO-B inhibition at recommended doses carries lower risk.
What this interaction means in plain words
Modafinil and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Potential additive pressor and CNS stimulant effects from MAO inhibition and modafinil's dopaminergic and noradrenergic actions.
What to do
Monitor blood pressure and for agitation or insomnia when combining them. Keep rasagiline at the recommended dose to preserve MAO-B selectivity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Modafinil with Rasagiline?
MediHelp rates the interaction as moderate. Modafinil and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a selective MAO-B inhibitor and modafinil is a wake-promoting agent with some catecholaminergic activity. Labeling advises caution with MAO inhibitors, as hypertensive reactions are theoretically possible, although selective MAO-B inhibition at recommended doses carries lower risk.
How serious is the interaction between Modafinil and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for agitation or insomnia when combining them. Keep rasagiline at the recommended dose to preserve MAO-B selectivity.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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