Drug interactions
Modafinil + Sofosbuvir-velpatasvir
Severity: Minor
Modafinil and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir is a weak CYP3A4 inhibitor and modafinil is partly metabolized by CYP3A4, so a small rise in modafinil levels is possible. Modafinil has a wide therapeutic margin, so any effect is minor.
What this interaction means in plain words
Modafinil and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir may weakly inhibit CYP3A4 metabolism of modafinil.
What to do
No dose adjustment is needed. Monitor for insomnia, anxiety or headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Modafinil and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir is a weak CYP3A4 inhibitor and modafinil is partly metabolized by CYP3A4, so a small rise in modafinil levels is possible. Modafinil has a wide therapeutic margin, so any effect is minor.
How serious is the interaction between Modafinil and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for insomnia, anxiety or headache.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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