Drug interactions
Moexipril + Pregabalin
Severity: Moderate
Moexipril and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and pregabalin have been associated with angioedema of the face, mouth and neck. Using them together may increase the chance of this reaction, which can compromise the airway.
What this interaction means in plain words
Moexipril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Both drugs can independently cause angioedema; the combined risk is additive but the mechanism for pregabalin is not well established.
What to do
Counsel patients to seek urgent care for swelling of the lips, tongue or throat. Stop the drugs and treat promptly if angioedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Moexipril with Pregabalin?
MediHelp rates the interaction as moderate. Moexipril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and pregabalin have been associated with angioedema of the face, mouth and neck. Using them together may increase the chance of this reaction, which can compromise the airway.
How serious is the interaction between Moexipril and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the lips, tongue or throat. Stop the drugs and treat promptly if angioedema develops.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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