Drug interactions
Moexipril + Temsirolimus
Severity: Major
Moexipril and Temsirolimus: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus, an mTOR inhibitor, combined with an ACE inhibitor increases the risk of angioedema. Reactions can involve the face, lips, tongue or airway and may be serious.
What this interaction means in plain words
Moexipril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moexipril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Additive angioedema risk from bradykinin accumulation with ACE inhibition and mTOR inhibition.
What to do
Counsel patients to report any swelling or breathing difficulty immediately. Discontinue moexipril and switch to a non-ACE inhibitor antihypertensive if angioedema develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Moexipril with Temsirolimus?
MediHelp rates the interaction as major. Moexipril and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temsirolimus, an mTOR inhibitor, combined with an ACE inhibitor increases the risk of angioedema. Reactions can involve the face, lips, tongue or airway and may be serious.
How serious is the interaction between Moexipril and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report any swelling or breathing difficulty immediately. Discontinue moexipril and switch to a non-ACE inhibitor antihypertensive if angioedema develops.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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