Drug interactions
Molindone + Vilazodone
Severity: Moderate
Molindone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A serotonergic antidepressant combined with a dopamine-blocking antipsychotic can rarely cause serotonin syndrome or neuroleptic malignant syndrome. Additive sedation may also occur.
What this interaction means in plain words
Molindone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic interaction between serotonergic enhancement and dopamine receptor blockade.
What to do
Monitor for mental status change, fever, rigidity and autonomic instability, particularly after starting or increasing doses. Discontinue the agents if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Molindone with Vilazodone?
MediHelp rates the interaction as moderate. Molindone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A serotonergic antidepressant combined with a dopamine-blocking antipsychotic can rarely cause serotonin syndrome or neuroleptic malignant syndrome. Additive sedation may also occur.
How serious is the interaction between Molindone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, fever, rigidity and autonomic instability, particularly after starting or increasing doses. Discontinue the agents if toxicity is suspected.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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