Drug interactions
Momelotinib + Pitavastatin
Severity: Moderate
Momelotinib and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib may increase pitavastatin exposure and the risk of dose-related statin adverse effects such as myopathy.
What this interaction means in plain words
Momelotinib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Momelotinib belongs to Oncology; Pitavastatin belongs to Cardiovascular.
Why it happens
Momelotinib inhibits BCRP, reducing pitavastatin efflux and increasing exposure.
What to do
Monitor for muscle symptoms and consider reducing the pitavastatin dose. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Momelotinib and Pitavastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pitavastatin
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Pitavastatin?
MediHelp rates the interaction as moderate. Momelotinib and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib may increase pitavastatin exposure and the risk of dose-related statin adverse effects such as myopathy.
How serious is the interaction between Momelotinib and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider reducing the pitavastatin dose. Check CK if symptoms occur.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
